Bioidentical Progesterone is the same as Natural Progesterone. So buy a natural progesterone cream. The biggest problem with most of the progesterone creams is that the cream base which the progesterone is suspended in has some kind of chemical or herb that mimics estrogen or blocks progesterone.
Many of the herbs used in hormone creams are progesterone blocking. For instance, aloe if taken in sufficient quantity during the 1st trimester of pregnancy is used to create miscarriages. Progesterone is the hormone of pregnancy. And you need enough progesterone to get to stimulate the progesterone receptor to maintain the pregnancy. If an herb blocks the progesterone receptor binding to it and no stimulating it and blocking the progesterone hormone, then you will get a miscarriage. Aloe is a progesterone blocker.
Unfortunately, many commercial progesterone creams contain aloe; a known progesterone blocker. This is insanity.
Many progesterone cream contain sunflower oil, a known hormone disrupter. Coumestrol found in sunflower seeds when fed to the mother rat caused permanent reproductive problems in the rat pups: female pups when grown did not ovulate, and the male pups had altered mounting behavior and fewer ejaculations. Neonatal rats and immature rats exposed to coumestrol had premature estrous cycles. I had one endometriosis patient report that her endometriosis flared when she binged on potato chip cooked in sunflower oil. Sunflower oil in progesterone cream is crazy, but sunflower oil is cheap.
Rosemary is a known estrogen mimic. Rosemary is used as an antioxidant and a plant estrogen for hot flashes and menopause. Rosemary has made my endometriosis patients much worse and made uterine fibroids bigger. And yes, some progesterone creams contain rosemary.
Those are just some of the herbs that are a problem. There are many others.
Some progesterone creams may contain mineral oil. Mineral oil is oil pumped from oil rigs from under the ground. The advantage of mineral is that it is very cheap and does not go rancid. However, John Lee, MD found that mineral oil in progesterone cream blocked the skin absorption of progesterone. If the cream contains lots of mineral oil, the patient did not absorb progesterone. This is more craziness.
The patient usually needs 20-60 mg/day of bioidentical progesterone. Some creams contain too much progesterone and some creams not enough. John Lee, MD recommends a cream that has 500-1000 mg per ounce of progesterone.
A cream is just oil and water mixed together with a thickener. The progesterone is in the oil fraction of the cream. Within several minutes of applying the cream to the skin, the water evaporates and only the oil is left on the skin. You need a chemical to keep the water and oil mixed together called an emulsifier. Since water is in the product, you also need a preservative to stop bacteria and fungus from growing in the water.
One of the early creams that I tried using on my patients in 1999, was a cream that contained Stearyl Konium Chloride. Stearly Konium Chloride is an emulsifier and preservative together. I gave it to my patient. However, 3 months later, I checked the old University of Texas database Material Data and Safety Sheet on Stearyl Konium Chloride. I found that 3ml of Stearyl Konium Chloride taken orally produced fatal convulsions in adults. This was shocking. "How much was in the bottle?", I wondered. It turns out that if you ate a third of the bottle, you would die with fatal convulsions. Are they crazy? Stearyl Konium Chloride may also be absorbed by the skin.
Common preservatives such as parabens and phenoxyethanol are proven estrogen mimics. Why would you want to put in a preservative that is estrogenic in a progesterone cream, if you are taking the progesterone cream to balance out the excess estrogen?
For many years, parabens were considered among those preservatives with low systemic toxicity, primarily causing allergic reactions. However, as we have become aware that some synthetic chemicals mimic the female hormone estrogen, our understanding of the toxic effects of both synthetic and natural substances has changed. Now, John Sumpter from the Department of Biology & Biochemistry, Brunel University, Uxbridge, Middlesex, have found that alkyl hydroxy benzoate preservatives (namely methyl-, ethyl-, propyl-, and butylparaben) are weakly estrogenic. In an estrogen receptor-binding assay, butylparaben was able to compete with the female hormone estradiol for binding to estrogen receptors with an affinity approximately 5 orders of magnitude lower than that of diethylstilbestrol (a highly carcinogenic synthetic estrogen), and between 1 and 2 orders of magnitude less than nonylphenol (an estrogenic synthetic industrial chemical).
Although it is reassuring to note that when administered orally, the parabens were inactive, subcutaneous administration of butylparaben produced a positive estrogenic response on uterine tissues. Although approximately 100,000 times less potent than17 beta-estradiol, greater exposure to the parabens may compensate for their lower potency. The researchers conclude that, "Given their use in a wide range of commercially available topical preparations, it is suggested that the safety in use of these chemicals should be reassessed . . ."
The European Union has asked the European Cosmetics and Toiletry industry about these new findings and the implication for breast cancer.
So if rosemary on the skin can make fibroids bigger, what else on the skin can make fibroids bigger? It turns out that anything that you put on the skin is 10 times in potency than what you take orally. For instance, a 20 mg topical dose of progesterone is equivalent to a 200 mg oral progesterone dose. This is because the liver 90% inactivates progesterone taken by mouth. However, the topical preparation bypasses the liver and goes directly into the body.
OK. If skin absorption is so important, then anything put on the skin must be watched carefully. This includes laundry detergent, soap, shampoo, deodorant, and cosmetics.
Here is a company that just makes bioidentical natural progesterone in coconut oil. No preservatives and no emulsifiers are in the formulation. Also included with the product is an avoidance list. It is messier than a cream, but you don't have to worry about all the other ingredients that may cause problems. Again the water just evaporates after a couple of minutes on the skin anyway. You really don't need the water for it to work. The progesterone is dissolved in the oil. It is messier than the cream. And the coconut oil does combine with some women's sweat (but not all women), to give a strange smell on the skin. However, I do get significantly better results getting women well. If you are really good about your avoidance list many women do not need the progesterone cream after a while.
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